Cellular and biochemical analyses of TDP1 mediated chromosomal break repair

0044 English OPEN
Wells, Owen Spencer;
(2014)
  • Subject: QH460

Tyrosyl DNA phosphodiesterase 1 (TDP1) is an end- rocessing enzyme involved in the repair of abortive topoisomerase I (Top1) complexes. Although not essential for survival, a hypomorphic mutation in TDP1 is linked to the autosomal recessive ataxia, spinocerebellar ataxi... View more
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