Synthetic strategies towards challenging PPI drug targets

0044 English OPEN
Moore, Thomas Oliver;
(2016)
  • Subject: QD0415

Protein-protein interactions (PPIs) present a challenging target for the development of\ud inhibitors, due to the large size and lipophilicity of protein binding sites. Because of this,\ud work that is able to increase our understanding of how PPI inhibitors can be bett... View more
  • References (251)
    251 references, page 1 of 26

    1 Introduction..............................................................................................................1

    1.1 The Search for a New Generation of Drug Targets ......................................1

    1.1.1 Protein-Protein Interactions (PPIs) Make Difficult Drug Targets ..............2

    1.2 Assessing PPIs for Druggability......................................................................3

    1.2.1 Using Computational Methods to Test PPI Druggability ...........................4

    1.3 Designing Protein Mimetics to Inhibit PPIs...................................................7

    1.3.1 Using Foldamers to Inhibit PPIs .................................................................8

    1.3.2 Using Designed Miniproteins to Inhibit PPIs ...........................................10

    1.3.3 Using Stapled Helices to Inhibit PPIs .......................................................28

    1.3.4 Using small molecule α-helical mimetics to inhibit PPIs .........................36

  • Bioentities (1)
    2o8t Protein Data Bank
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