Electrophysiological evidence of early functional damage in glaucoma and ocular hypertension

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North, Rachel Valerie; Jones, Adrian L.; Drasdo, Neville; Wild, John Millington; Morgan, James Edwards;
  • Publisher: Association for Research in Vision and Ophthalmology
  • Identifiers: doi: 10.1167/iovs.09-3409
  • Subject: RE
    mesheuropmc: eye diseases | genetic structures | sense organs

Purpose. The quantification of early retinal ganglion cell damage in ocular hypertension and glaucoma. \ud \ud Methods. Thirty subjects under treatment for open-angle glaucoma, 23 subjects with ocular hypertension, and 28 healthy subjects in a control group were investi... View more
  • References (54)
    54 references, page 1 of 6

    1. Weber AJ, Kaufman PL, Hubbard WC. Morphology of single ganglion cells in the glaucomatous primate. Invest Ophthalmol Vis Sci. 1998;39:2304 -2320.

    2. Weber AJ, Harman, CD. Structure-function relations of parasol cells in the normal and glaucomatous primate retina. Invest Ophthalmol Vis Sci. 2005;46:3197-3207.

    3. Shou T, Liu J, Wang W, Zhou Y, Zhao K. Differential dendritic shrinkage of alpha and beta retinal ganglion cells in cats with chronic glaucoma. Invest Ophthalmol Vis Sci. 2003;44:3005- 3010.

    4. Morgan JE, Datta AV, Erichsen JT, Albon J, Boulton ME. Retinal ganglion cell remodelling in experimental glaucoma. Adv Exp Med Biol. 2006;572:397- 402.

    5. Buckingham BP, Inman DM, Lambert W, et al. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J Neurosci. 2008;28(11):2735-2744.

    6. Holcombe D, Lengefeld N, Gole GA, Barnett NL. Selective inner retinal dysfunction precedes ganglion cell loss in a mouse glaucoma model. Br J Ophthalmol. 2008;92(5):683- 688.

    7. Sommer A, Tielsch JM, Katz J, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol. 1991;109:77- 83.

    8. Kamal DS, Viswanathan AC, Garway-Heath DF, et al. Detection of optic disc change with the Heidelberg retina tomograph before confirmed visual field change in ocular hypertensives converting to early glaucoma. Br J Ophthalmol. 1999;83:290 -294.

    9. Tuulonen A, Lehtola J, Airaksinen PJ. Nerve fiber layer defects with normal visual fields: do normal optic disc and normal visual field indicate absence of glaucomatous abnormality? Ophthalmology. 1993;100:587-597.

    10. Harwerth RS, Carter-Dawson L, Shen F, et al. Ganglion cell losses underlying visual field defects from experimental glaucoma. Invest Ophthalmol Vis Sci. 1999;40:2242-2250.

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