Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

Article English OPEN
Jansen, IE; Ye, H; Heetveld, S; Lechler, MC; Michels, H; Seinstra, RI; Lubbe, SJ; Drouet, V; Lesage, S; Majounie, E; Gibbs, JR; Nalls, MA; Ryten, M; Botia, JA; Vandrovcova, J; Simon-Sanchez, J; Castillo-Lizardo, M; Rizzu, P; Blauwendraat, C; Chouhan, AK; Li, Y; Yogi, P; Amin, N; van Duijn, CM; Morris, HR; Brice, A; Singleton, AB; David, DC; Nollen, EA; Jain, S; ... view all 74 authors
  • Publisher: BioMed Central

Background: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson's disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated participants. To discover rare PD susceptibility va... View more