publication . Article . 2011

Do lutein, zeaxanthin and macular pigment optical density differ with age or age-related maculopathy?

Emma J. Berrow; Hannah E. Bartlett; Frank Eperjesi;
Open Access English
  • Published: 01 Aug 2011
  • Country: United Kingdom
Background and aims Current age-related macular disease (ARMD) treatment includes antioxidant supplementation. Lutein (L) and zeaxanthin (Z) are antioxidants that make up macularpigment within the retina and may reduce the risk of developing ARMD. Ageing and smoking are leading risk factors for developing ARMD. We investigated differences in dietary, supplemental and retinal L and Z, and smoking habits in healthy younger eyes (HY), healthy older eyes (HO) and eyes with an early form of ARMD called age-related maculopathy (ARM). Methods HO, HY and ARM groups were assessed for dietary intakes of L and Z using food diaries. Smoking habits and self-administered quan...
Medical Subject Headings: eye diseases
free text keywords: Endocrinology, Diabetes and Metabolism, Optometry, Zeaxanthin, chemistry.chemical_compound, chemistry, Maculopathy, medicine.disease, medicine, Intensive care medicine, medicine.medical_specialty, Ophthalmology, Lutein, Age-related maculopathy, Macular Pigment, Ageing, Retinal, business.industry, business, Diabetes mellitus
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43 references, page 1 of 3

1. Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol 1995;39:367-374. [OpenAIRE]

2. Evans J, Wormald R. Is the incidence of registrable age-related macular degeneration increasing? Br J Ophthalmol 1996;80:9-14.

3. Curcio C, Millican C. Basal linear deposit and large drusen are specific for early agerelated maculopathy. Archives of Ophthalmology 1999;117:329-339. [OpenAIRE]

4. The AREDS Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss - AREDS Report No. 8. Archives of Ophthalmology 2001;119:1417-1436.

5. Bone R, Landrum J, Tarsis S. Preliminary identification of the human macular pigment. Vision Res 1985;25:1531-1535.

6. Hammond BR, Wooten BR, Snodderly DM. Individual variations in the spatial profile of human macular pigment. Journal of the Optical Society of America a-Optics Image Science and Vision 1997;14:1187-1196. [OpenAIRE]

7. Snodderly DM, Auran J, Delori F. The macular pigment II. Spatial distribution in primate retinas. Investigative Ophthalmological Vision Science 1984;25:674-685. [OpenAIRE]

8. Snodderly DM, Brown B, Delori F. The macular pigment I. Absorbance spectra, localisation, and discrimination from other yellow pigments in primate retinas. Investigative Ophthalmological Vision Science 1984;25:660-673. [OpenAIRE]

9. Organisciak DT, Vaughan DK. Retinal light damage: mechanisms and protection. Prog Retin Eye Res 2009;29:113-134.

10. Krinsky NID, S.M. Interaction of oxygen and oxy-radicals with carotenoids. J Natl Cancer Inst 1982;69:205-210.

11. Bone RA, Landrum JT, Mayne ST, Gomez CM, Tibor SE, Twaroska EE. Macular pigment in donor eyes with and without AMD: a case-control study. Invest Ophthalmol Vis Sci 2001;42:235-240.

12. Delcourt C, Carriere I, Delage M, Barberger-Gateau P, Schalch W. Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study. Invest Ophthalmol Vis Sci 2006;47:2329-2335.

13. Mares-Perlman JA, Brady WE, Klein R, et al. Serum antioxidants and age-related macular degeneration in a population-based case-controlled study. Archives of Ophthalmology 1995;113:1518-1523. [OpenAIRE]

14. MaresPerlman JA, Klein R, Klein BEK, et al. Association of zinc and antioxidant nutrients with age-related maculopathy. Archives of Ophthalmology 1996;114:991-997.

15. Richer S. ARMD--pilot (case series) environmental intervention data. J Am Optom Assoc 1999;70:24-36.

43 references, page 1 of 3
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