publication . Article . Other literature type . 2018

Inconsistent MHC class II association in Beagles experimentally infected with Leishmania infantum

Soutter, F.; Martorell, S.; Solano-Gallego, L.; Catchpole, B.;
Open Access English
  • Published: 07 Mar 2018
  • Country: United Kingdom
Abstract
Abstract The clinical outcome of Leishmania infantum infection in dogs varies from subclinical infection to severe disease. Researchers attribute this variability in clinical manifestations to the ability of the immune response to limit pathogen multiplication and dissemination, which is, in part, likely determined by the immune response genes. The aim of this study was to test the hypothesis that MHC class II genes are associated with disease outcome of experimental L. infantum infection in Beagles. Dog leukocyte antigen (DLA) class II haplotypes were characterised by sequence-based typing of Beagle dogs experimentally infected with L. infantum during vaccine c...
Subjects
Medical Subject Headings: parasitic diseases
free text keywords: Animal Science and Zoology, General Veterinary, Serology, Dog leukocyte antigen, biology.protein, biology, Leishmania infantum, biology.organism_classification, Subclinical infection, Virology, Antibody, Leishmania, Parasite load, Immune system
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