publication . Thesis

Mechanism of resistance to oestrogen deprivation in breast cancer.

Staka, Cindy M.;
Open Access English
  • Country: United Kingdom
Abstract
Oestrogen deprivation strategies, notably aromatase inhibitors, are of increasing value in hormone sensitive breast cancer. Unfortunately, however, oestrogen deprivation, like all other antihormones, is subject to acquisition of resistance. Further understanding of resistance is required to design approaches to effectively treat this state. This project aimed to delineate and target the underlying autocrine signalling mechanisms promoting this resistant phenotype, using a unique severely oestrogen and growth factor deprived in vitro breast cancer model, MCF-7X. The MCF-7X model revealed breast cancer cells are readily able to survive oestrogen deprivation, but a...
Subjects
Medical Subject Headings: skin and connective tissue diseases
free text keywords: RC0254, RM
Related Organizations
488 references, page 1 of 33

1.3.3 Aromatase Inhibitors/ Inactivators versus Tamoxifen in

1.3.3.1 Adjuvant Trials: Advanced Breast Cancer

1.3.3.2 Adjuvant Trials: Early Breast Cancer

1.3.3.3. Neoadjuvant Trials

1.3.4 Ovarian Ablation/ Suppression in Premenopausal

1.3.5 Future Development Studies and Research

1.4 DEVELOPMENT OF THE OESTROGEN DEPRIVATION

1.5 AIMS AND OBJECTIVES

CHAPTER 2 MATERIALS AND METHODS

2.1 MATERIALS

2.2 CELL CULTURE

2.2.1 Routine Maintenance o f MCF-7 Cells

2.2.2 Routine Maintenance o f MCF-7X cells

2.2.3 Dose Response Assays

2.2.4 Growth Stimulation Assays

488 references, page 1 of 33
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