publication . Article . 2004

Are there functional consequences of a reduction in selenium intake in UK subjects?

Jackson, Malcolm J; Dillon, Stephanie; Broome, Caroline S; McArdle, Anne; Hart, C Anthony; McArdle, Francis;
Open Access
  • Published: 01 Nov 2004 Journal: Proceedings of the Nutrition Society, volume 63, pages 513-517 (issn: 0029-6651, eissn: 1475-2719, Copyright policy)
  • Publisher: Cambridge University Press (CUP)
  • Country: United Kingdom
<jats:p>Dietary Se levels in the UK have fallen over the last 20 years and recent surveys indicate that average Se intakes are 30–40 μg/d, which is well below the current UK reference nutrient intake for adult men (75 μg/d) or women (60 μg/d). Functional consequences of this decline have not been recognised, although epidemiological data suggest it may contribute to increased risk of infections and incidence of some cancers. Previous data have indicated that biochemical changes in Se-dependent proteins occur in otherwise healthy UK subjects given small Se supplements. The current studies have focused on the effect of small Se supplements on the immune response s...
free text keywords: Nutrition and Dietetics, Medicine (miscellaneous), Immune system, Poliovirus, medicine.disease_cause, medicine, Epidemiology, medicine.medical_specialty, Selenium intake, Genetic variability, Viral replication, Attenuated vaccine, Immunology, business.industry, business
Related Organizations
34 references, page 1 of 3

Bates CJ, Thane CW, Prentice A & Delves HT (2002) Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 and over. Journal of Trace Elements in Medicine and Biology 16, 1-8. [OpenAIRE]

Beaglehole R, Jackson R, Watkinson J, Scragg R & Yee RL (1990) Decreased blood selenium and risk of myocardial infarction. International Journal of Epidemiology 19, 918-922.

Beck MA, Esworthy RS, Ho YS & Chu FF (1998) Glutathione peroxidase protects mice from viral-induced myocarditis. FASEB Journal 12, 1143-1149.

Beck MA, Shi Q, Morris VC & Levander OA (1995) Rapid genomic evolution of a non-virulent Coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates. Nature Medicine 1, 433-436.

Berr C, Nicole A, Godin J, Ceballos-Picot I, Thevenin M, Dartigues JF & Alperovitch A (1993) Selenium and oxygenmetabolizing enzymes in elderly community residents: a pilot epidemiological study. Journal of the American Geriatric Society 41, 143-148.

Bonomini M, Forster S, De-risio F, Rychly J, Nebe B & Manfrini V (1995) Effects of selenium supplementation on immune parameters in chronic uraemic patients on haemodialysis. Nephrology Dialysis and Transplantation 10, 1654-1661.

Broome CS, McArdle F, Kyle JA, Andrews F, Lowe NM, Hart CA, Arthur JR & Jackson MJ (2004) An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. American Journal of Clinical Nutrition 80, 154-162.

Brown KM, Pickard K, Nicol F, Beckett GJ, Duthie GG & Arthur JR (2000) Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphocytes, granulocytes, platelets and erythrocytes. Clinical Science 98, 593-599.

Burk RF (1989) Recent developments in trace element metabolism and function: newer roles of selenium in nutrition. Journal of Nutrition 119, 1051-1054. [OpenAIRE]

Campbell D, Bunker VW, Thomas AJ & Clayton BE (1989) Selenium and vitamin E status of healthy and institutionalized elderly subjects: analysis of plasma, erythrocytes and platelets. British Journal of Nutrition 62, 221-227.

Cermelli C, Vinceti M, Scaltriti E, Bazzani E, Beretti F, Vivoli G & Portolani M (2002) Selenite inhibition of Coxsackie virus B5 replication: implications on the etiology of Keshan disease. Journal of Trace Elements in Medicine and Biology 16, 41-46. [OpenAIRE]

Clark LC, Cantor KP & Allaway WH (1991) Selenium in forage crops and cancer mortality in US counties. Archives of Environmental Health 46, 37-42.

Clark LC, Combs GF Jr, Turnbull BW, Slate EH, Chalker DK, Chow J et al. (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. Journal of the American Medical Association 276, 1957-1963.

Combs GF Jr (2001) Selenium in global food systems. British Journal of Nutrition 85, 517-547.

Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 41. London: H.M. Stationery Office.

34 references, page 1 of 3
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue