Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Article English OPEN
Aschard, Hugues.; Tobin, Martin D..; Hancock, Dana B..; Skurnik, David.; Sood, Akshay.; James, Alan.; Vernon Smith, Albert.; Manichaikul, Ani W..; Campbell, Archie.; Prins, Bram P..; Hayward, Caroline.; Loth, Daan W..; Porteous, David J..; Strachan, David P..; Zeggini, Eleftheria.; O’Connor, George T..; Brusselle, Guy G..; Boezen, H. Marike.; Schulz, Holger.; Deary, Ian J..; Hall, Ian P..; Rudan, Igor.; Kaprio, Jaakko.; Wilson, James F..; Wilk, Jemma B..; Huffman, Jennifer E..; Hua Zhao, Jing.; de Jong, Kim.; Lyytikäinen, Leo-Pekka.; Wain, Louise V..; ... view all 51 authors
  • Publisher: Oxford University Press (OUP)
  • Subject:
    mesheuropmc: respiratory system | respiratory tract diseases

Background: Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been demonstrated, and at least 26 loci have been reproducibly associated with either FEV1 (forced expiratory volume... View more
Share - Bookmark