Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons\ud

Article English OPEN
Muraro, Nara I.; Weston, Andrew J.; Gerber, Andre P.; Luschnig, Stefan; Moffat, Kevin G.; Baines, Richard A.;
(2008)

Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (INa) and excitability in Drosophila motoneur... View more
  • References (48)
    48 references, page 1 of 5

    Asaoka-Taguchi M, Yamada M, Nakamura A, Hanyu K, Kobayashi S (1999) Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos. Nat Cell Biol 1:431- 437.

    Baines RA (2003) Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS. J Neurosci 23:8664 - 8672.

    Baines RA, Bate M (1998) Electrophysiological development of central neurons in the Drosophila embryo. J Neurosci 18:4673- 4683.

    Baines RA, Uhler JP, Thompson A, Sweeney ST, Bate M (2001) Altered electrical properties in Drosophila neurons developing without synaptic transmission. J Neurosci 21:1523-1531.

    Barker DD, Wang C, Moore J, Dickinson LK, Lehmann R (1992) Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos. Genes Dev 6:2312-2326.

    Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401- 415.

    Catterall WA, Goldin AL, Waxman SG (2005) International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 57:397- 409.

    Chagnovich D, Lehmann R (2001) Poly(A)-independent regulation of maternal hunchback translation in the Drosophila embryo. Proc Natl Acad Sci USA 98:11359 -11364.

    Cho PF, Gamberi C, Cho-Park YA, Cho-Park IB, Lasko P, Sonenberg N (2006) Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Curr Biol 16:2035-2041.

    Curtis D, Treiber DK, Tao F, Zamore PD, Williamson JR, Lehmann R (1997) A CCHC metal-binding domain in Nanos is essential for translational regulation. EMBO J 16:834 - 843.

  • Related Organizations (12)
  • Metrics
Share - Bookmark