Combined prednisolone and intravenous immunoglobulin treatment for acquired factor VIII inhibitors: a 2-year review

Article English OPEN
Dykes, A.C.; Walker, I.D.; Lowe, G.D.O.; Tait, R.C.;
  • Publisher: Blackwell Publishing
  • Subject: RC | RM | QP
    mesheuropmc: hemic and lymphatic diseases

Acquired inhibitors to factor VIII (FVIII) are rare, but life- threatening in up to 22% of cases. The optimal therapy for suppression of these inhibitors remains unclear. Prednisolone is the mainstay of therapy, producing responses in approximately 30% of cases. Intrave... View more
  • References (16)
    16 references, page 1 of 2

    1 Lottenberg R, Kentro TB, Kitchens CS. A natural history study of 16 patients with factor VIII inhibitors receiving little or no therapy. Arch Intern Med 1987; 147: 1077±81.

    2 Margolius A, Jackson DP, Ratnoff OD. Circulating anticoagulants: a study of 40 cases and a review of the literature. Medicine 1961; 40: 145±202.

    3 Shapiro SS, Hultin M. Acquired inhibitors to the blood coagulation factors. Semin Thromb Haemost 1975; 1: 336±85.

    4 Green D, Lechner K. A survey of 214 non-haemophiliac patients with inhibitors to factor VIII. Thromb Haemost 1981; 45: 200±3.

    5 Hay CRM, Negrier C, Ludlam CA. The treatment of bleeding in acquired haemophilia with recombinant factor VIIa. Thromb Haemost 1997; 78: 1463±7.

    6 Spero JA, Lewis JH, Hasiba U. Corticosteroid therapy for acquired FVIII:C inhibitors. Br J Haematol 1981; 48: 635±42.

    7 Green D, Rademaker AW, Briet E. A prospective randomised trial of prednisolone and cyclophosphamide in the treatment of patients with factor VIII antibodies. Thromb Haemost 1993; 70: 753±7.

    8 Sultan Y, Kazatchkine MD, Nydegger U, Rossi F, Dietrich G, Algiman M. Intravenous immunoglobulin in the treatment of spontaneously acquired factor VIII:C Inhibitors. Am J Medicine 1991; 91: 35S±39S.

    9 Herbst KD, Rapaport SI, Kenoyer DG, Stanton W, Feinstein DI. Syndrome of acquired inhibitor of factor VIII responsive to cyclophosphamide and prednisolone. Ann Intern Med 1981; 95: 575±8.

    10 Rizza CR, Edgcumbe JOP, Pitney WR, Child JA. The treatment of patients having spontaneously occuring antibodies to antihaemophilic factor (factor VIII). Thromb Diath Haemorrhag 1972; 28: 120±7.

  • Metrics
Share - Bookmark