Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression

Article English OPEN
Barber, M.; Langhorne, P.; Rumley, A.; Lowe, G.D.O.; Stott, D.J.;
  • Publisher: American Heart Association
  • Subject: RC

<p><b>Background and Purpose:</b> Early clinical progression of ischemic stroke is common and is associated with increased risk of death and dependency. We hypothesized that activation of the coagulation system is an important contributor in some cases... View more
  • References (35)
    35 references, page 1 of 4

    1. Tei H, Uchiyama S, Ohara K, Kobayashi M, Uchiyama Y, Fukuzawa M. Deteriorating ischemic stroke in 4 clinical categories classified by the Oxfordshire Community Stroke Project. Stroke. 2000;31:2049 -2054.

    2. Ro¨de´n-Ju¨llig Å. Progressing stroke: epidemiology. Cerebrovasc Dis. 1997;7:2-5.

    3. Barber M, Wright F, Stott DJ, Langhorne P. Predictors of early neurological deterioration after ischaemic stroke: a case control study. Gerontology. 2004;50:102-109.

    4. Ageno W, Finazzi S, Steidl L, Biotti MG, Mera V, Melzi DG, Venco A. Plasma measurement of D-dimer levels for the early diagnosis of ischemic stroke subtypes. Arch Intern Med. 2002;162:2589 -2593.

    5. Alte`s A, Abella´n MT, Mateo J, Avila A, Mart´ı-Vilalta JL, Fontcuberta J. Hemostatic disturbances in acute ischemic stroke: a study of 86 patients. Acta Haematol. 1995;94:10 -15.

    6. Lip G, Blann A, Farooqi I, Zarifis J, Sagar G, Beevers D. Abnormal haemorheology, endothelial function and thrombogenesis in relation to hypertension in acute (ictus 12 h) stroke patients: the West Birmingham Stroke Project. Blood Coagul Fibrinolysis. 2001;12:307-315.

    7. McConnell JP, Cheryk LA, Durocher A, Bruno A, Bang NU, Fleck JD, Williams L, Biller J, Meschia JF. Urinary 11-dehydro-thromboxane B(2) and coagulation activation markers measured within 24 h of human acute ischemic stroke. Neurosci Lett. 2001;313:88 -92.

    8. Tohgi H, Konno S, Takahashi S, Koizumi D, Kondo R, Takahashi H. Activated coagulation/fibrinolysis system and platelet function in acute thrombotic stroke patients with increased C-reactive protein levels. Thromb Res. 2000;100:373-379.

    9. Uchiyama S, Yamazaki M, Hara Y, Makato I. Alterations of platelet, coagulation, and fibrinolysis markers in patients with acute ischemic stroke. Semin Thromb Hemost. 1997;23:535-541.

    10. de Boer AC, Turpie AG, Butt RW, Duke RJ, Bloch RF, Genton E. Plasma betathromboglobulin and serum fragment E in acute partial stroke. Br J Haematol. 1982;50:327-334.

  • Metrics
Share - Bookmark