Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.

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PRISM Investigators; Rowan, KM; Angus, DC; Bailey, M; Barnato, AE; Bellomo, R; Canter, RR; Coats, TJ; Delaney, A; Gimbel, E; Grieve, RD; Harrison, DA; Higgins, AM; Howe, B; Huang, DT; Kellum, JA; Mouncey, PR; Music, E; Peake, SL; Pike, F; Reade, MC; Sadique, MZ; Singer, M; Yealy, DM; COLLABORATORS; Eaton, TL; Keener, C; Landis, K; Stapleton, DK; Weissfeld, LA; ... view all 479 authors
  • Publisher: Massachusetts Medical Society

: After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from ... View more
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