Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression

Article English OPEN
Morganstein, DL; Wu, P; Mane, MR; Fisk, NM; White, R; Parker, MG;
(2010)

We investigated the ability of fetal mesenchymal stem cells (fMSCs) to differentiate into brown and white adipocytes and compared the expression of a number of marker genes and key regulatory factors. We showed that the expression of key adipocyte regulators and markers... View more
  • References (33)
    33 references, page 1 of 4

    1. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004; 84(1):277-359. [PubMed: 14715917]

    2. Farmer SR. Transcriptional control of adipocyte formation. Cell Metabolism. 2006; 4(4):263-73. [PubMed: 17011499]

    3. Smas CM, Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell. 1993; 73(4):725-34. [PubMed: 8500166]

    4. Lee K, Villena JA, Moon YS, et al. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). J Clin Invest. 2003; 111(4):453-61. [PubMed: 12588883]

    5. Moon YS, Smas CM, Lee K, et al. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity. Mol Cell Biol. 2002; 22(15):5585-92. [PubMed: 12101250]

    6. Timmons JA, Wennmalm K, Larsson O, et al. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. PNAS. 2007; 104(11):4401-6. [PubMed: 17360536]

    7. Crisan M, Casteilla L, Lehr L, et al. A Reservoir of Brown Adipocyte Progenitors in Human Skeletal Muscle. Stem Cells. 2008; 26(9):2425-33. [PubMed: 18617684]

    8. Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008; 454(7207):961-7. [PubMed: 18719582]

    9. Seale P, Kajimura S, Yang W, et al. Transcriptional Control of Brown Fat Determination by PRDM16. Cell Metab. 2007; 6(1):38-54. [PubMed: 17618855]

    10. Puigserver P, Wu Z, Park CW, et al. A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis. Cell. 1998; 92(6):829-39. [PubMed: 9529258]

  • Similar Research Results (1)
  • Related Organizations (2)
  • Metrics
Share - Bookmark