publication . Thesis

Malignant Glioma: Chemosensitivity testing and Biomarkers

Lekka, Elvira;
Open Access English
  • Country: United Kingdom
Abstract
Chemosensitivity testing and molecular biomarkers are commonly used methods during the management of several types of malignant tumours in routine clinical practice. The present work attempts to transfer the use of these two concepts to the management of malignant gliomas. \ud Chemosensitivity testing was performed on twelve primary malignant glioma cultures at passage 0. The drugs tested were Temozolomide, Cisplatin and Carmustine, which are commonly administered chemotherapeutic agents in clinical practice in our institution. The results revealed that cultures derived from females or from patients under 65 years of age were more sensitive to the drugs used. Mo...
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