Photoreactivity of aged human RPE melanosomes: A comparison with lipofuscin

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Rozanowska, Malgorzata Barbara; Korytowski, Witold; Rozanowski, Bartosz; Skumatz, Christine; Boulton, Michael Edwin; Burke, Janice M.; Sarna, Tadeusz;
(2002)
  • Publisher: Association for Research in Vision and Ophthalmology
  • Subject:
    mesheuropmc: eye diseases | sense organs

purpose. To determine whether aging is accompanied by changes in aerobic photoreactivity of retinal pigment epithelial (RPE) melanosomes isolated from human donors of different ages, and to compare the photoreactivity of aged melanosomes with that of RPE lipofuscin.\ud ... View more
  • References (57)
    57 references, page 1 of 6

    1. Rozanowska M, Boulton ME, Burke JM, Korytowski W, Jarvis-Evans J, Sarna T. Blue light-induced reactivity of retinal pigment epithelium: in vitro oxygen uptake and formation of hydroperoxides. J Biol Chem. 1995;270:18825-18830.

    2. Boulton M. Melanin and the retinal pigment epithelium. In: Marmor MF, Wolfensberger TJ, eds. The Retinal Pigment Epithelium. Function and Disease. New York: Oxford University Press; 1998: 68 - 85.

    3. Campochiaro PA, Hackett SF. Corneal endothelial cell matrix promotes expression of differentiated features of retinal pigmented epithelial cells: implication of laminin and basic fibroblast growth factor as active components. Exp Eye Res. 1993;57:539 -547.

    4. Kurtz MJ, Edwards RB. Influence of bicarbonate and insulin on pigment synthesis by cultured adult human retinal pigment epithelial cells. Exp Eye Res. 1991;53:681- 684.

    5. Dorey CK, Torres X, Swart T. Evidence of melanogenesis in porcine retinal pigment epithelial. in vitro. Exp Eye Res. 1990;50:1- 10.

    6. Schraermeyer U, Stieve H. A newly discovered pathway of melanin formation in cultured retinal pigment epithelium of cattle. Cell Tissue Res. 1994;276:273-279.

    7. Schraermeyer U, Heimann K. Current understanding of the role of retinal pigment epithelium and its pigmentation. Pigment Cell Res. 1999;12:219 -236.

    8. Sarna T. Properties and function of the ocular melanin - a photobiophysical view. J Photochem Photobiol B. 1992;12:215-258.

    9. Handelman GJ, Dratz EA. The role of antioxidants in the retina and retinal pigment epithelium and the nature of prooxidant induced damage. Adv Free Radic Biol Med. 1986;2:1- 89.

    10. Boulton M, Docchio F, Dayhaw-Barker P, Ramponi R, Cubeddu R. Age-related changes in the morphology, absorption and fluorescence of melanosomes and lipofuscin granules of the retinal pigment epithelium. Vision Res. 1990;30:1291-1303.

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