Metformin reverses development of pulmonary hypertension via aromatase inhibition

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Dean, Afshan; Nilsen, Margaret; Loughlin, Lynn; Salt, Ian P.; MacLean, Margaret R.;
  • Publisher: American Heart Association

Females are more susceptible to pulmonary arterial hypertension than males, although the reasons remain unclear. The hypoglycemic drug, metformin, is reported to have multiple actions, including the inhibition of aromatase and stimulation of AMP-activated protein kinase... View more
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