Polymorphism in glutathione S-transferase P1 is\ud associated with susceptibility to chemotherapyinduced\ud leukemia

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Allan, J.M.; Wild, C.P.; Rollinson, S.; Willett, E.V.; Moorman, A.V.; Dovey, G.J.; Roddam, P.L.; Roman, E.; Cartwright, R.A.; Morgan, G.J.;
  • Subject:
    mesheuropmc: hemic and lymphatic diseases | neoplasms

Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens. Functional polymorphisms exist in at least three genes that en... View more
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