Heat shock proteins in health and disease: therapeutic targets or therapeutic agents?\ud \ud

Article English OPEN
Pockley, A.G.;
(2001)

For many years, heat shock or stress proteins have been regarded as intracellular molecules that have a range of housekeeping and cytoprotective functions, only being released into the extracellular environment in pathological situations such as necrotic cell death. How... View more
  • References (166)
    166 references, page 1 of 17

    1 Ritossa, F.A. (1962) A new puffing pattern induced by temperature shock and DNP in Drosophila. Experientia 18, 571-573

    2 Tissieres, A., Mitchell, H.K. and Tracy, U.M. (1974) Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J Mol Biol 84, 389-398., PubMed ID: 75214244

    3 Hightower, L.E. (1991) Heat shock, stress proteins, chaperones, and proteotoxicity. Cell 66, 191-197, PubMed ID: 91309134

    4 Gething, M.J. and Sambrook, J. (1992) Protein folding in the cell. Nature 355, 33-45, PubMed ID: 92114932

    5 Lindquist, S. and Craig, E.A. (1988) The heatshock proteins. Annu Rev Genet 22, 631-677, PubMed ID: 89192244

    6 Welch, W.J. (1993) How cells respond to stress. Sci Am 268, 56-64, PubMed ID: 93242380

    7 Voellmy, R. (1994) Transduction of the stress signal and mechanisms of transcriptional regulation of heat shock/stress protein gene expression in higher eukaryotes. Crit Rev Eukaryot Gene Expr 4, 357-401, PubMed ID: 95252683

    8 Morimoto, R.I. et al. (1994) Regulation of heat shock gene transcription by a family of heat shock factors. In The Biology of Heat Shock Proteins and Molecular Chaperones (Morimoto, R., Tissières, A. and Georgopoulos, C., eds), pp. 417-455, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, USA

    9 Knauf, U. et al. (1996) Repression of human heat shock factor 1 activity at control temperature by phosphorylation. Genes Dev 10, 2782-2793, PubMed ID: 97102678

    10 Kim, J. et al. (1997) Analysis of the phosphorylation of human heat shock transcription factor-1 by MAP kinase family members. J Cell Biochem 67, 43-54, PubMed ID: 97469376

  • Metrics
Share - Bookmark