Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Article English OPEN
Day, F.R.; Thompson, D.J.; Helgason, H.; Chasman, D.I.; Finucane, H.; Sulem, P.; Ruth, K.S.; Whalen, S.; Sarkar, A.K.; Albrecht, E.; Altmaier, E.; Amini, M.; Barbieri, C.M.; Boutin, T.; Campbell, A.; Demerath, E.; Giri, A.; He, C.; Hottenga, J.J.; Karlsson, R.; Kolcic, I.; Loh, P.-R.; Lunetta, K.L.; Mangino, M.; Marco, B.; McMahon, G.; Medland, S.E.; Nolte, I.M.; Noordam, R.; Nutile, T.; ... view all 222 authors
  • Publisher: Nature Publishing Group

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10(-8)) for age at menarc... View more
Share - Bookmark