publication . Other literature type . Article . 2018

Identification of anti-cancer potential of doxazocin: Loading into chitosan based biodegradable hydrogels for on-site delivery to treat cervical cancer

Jamal, A.; Shahzadi, L.; Ahtzaz, S.; Zahid, S.; Chaudhry, A.A.; Rehman, I.U.; Yar, M.;
  • Published: 01 Jan 2018
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
In this study, an effective, biocompatible and biodegradable co-polymer comprising of chitosan (CS) and polyvinyl alcohol (PVA) hydrogels, chemically crosslinked and impregnated with doxazocin, is reported. The chemical structural properties of the hydrogels were evaluated by Fourier Transform Infrared spectroscopy (FTIR) and physical properties were analysed by scanning electron microscopy (SEM). The swelling behaviour is an important parameter for drug release mechanism and was investigated to find out the solution absorption capacity of the synthesized hydrogels. MTT assay revealed that doxazocin loaded hydrogels significantly hindered the cell viability. Flo...
Subjects
Medical Subject Headings: technology, industry, and agriculturemacromolecular substances
free text keywords: Polyvinyl alcohol, chemistry.chemical_compound, chemistry, Materials science, In vivo, Viability assay, Nanotechnology, Swelling, medicine.symptom, medicine, Self-healing hydrogels, Nuclear chemistry, MTT assay, Fourier transform infrared spectroscopy, Organic chemistry, Chitosan
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