Short chain fatty acids (SCFA), principally acetate, propionate, butyrate and valerate, are produced in pharmacologically relevant concentrations by the gut microbiome. Investigations indicate that they exert beneficial effects on colon epithelia. There is increasing in... View more
4 S. Siavoshian, H. M. Blottiere, E. Le Foll, B. Kaeffer, C. Cherbut and J. P. Galmiche, Comparison of the effect of different short chain fatty acids on the growth and differentiation of human colonic carcinoma cell lines in vitro, Cell Biol. Int., 1997, 21(5), 281-287.
5 B. F. Hinnebusch, S. Meng, J. T. Wu, S. Y. Archer and R. A. Hodin, The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation, J. Nutr., 2002, 132(5), 1012-1017.
6 B. M. Corfe, Hypothesis: butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation, Mol. BioSyst., 2012, 8, 4.
7 E. P. Candido, R. Reeves and J. R. Davie, Sodium butyrate inhibits histone deacetylation in cultured cells, Cell, 1978, 14(1), 105-113.
8 S. M. Astbury and B. M. Corfe, Uptake and Metabolism of the Short-Chain Fatty Acid Butyrate, a Critical Review of the Literature, Curr. Drug Metab., 2012, 13(6), 815-921.
9 P. Verdier-Pinard, E. Pasquier, H. Xiao, B. Burd, C. Villard and D. Lafitte, et al., Tubulin proteomics: towards breaking the code, Anal. Biochem., 2009, 384(2), 197-206.
10 K. J. Verhey and J. Gaertig, The tubulin code, Cell Cycle, 2007, 6(17), 2152-2160.
11 D. N. Drechsel, A. A. Hyman, M. H. Cobb and M. W. Kirschner, Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau, Mol. Biol. Cell, 1992, 3(10), 1141-1154.
12 A. Desai and T. J. Mitchison, Microtubule polymerization dynamics, Annu. Rev. Cell Dev. Biol., 1997, 13, 83-117.
13 C. Bonfils, N. Bec, B. Lacroix, M. C. Harricane and C. Larroque, Kinetic analysis of tubulin assembly in the presence of the microtubule-associated protein TOGp, J. Biol. Chem., 2007, 282(8), 5570-5581.