A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells

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Al-Azzawi, Buthainah;
(2017)
  • Subject: RM

Diabetes is a lifelong condition caused by an inability of the body to break down glucose due to a defect in either insulin synthesis or the target cells becoming resistant to secreted insulin. There are two main types of diabetes, type 1 diabetes mellitus (T1DM) and ty... View more
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    1.7.3 IL-1β ------------------------------------------------------------------------------------------------ 23

    1.7.4 Bacterial Lipopolysaccharide (LPS)--------------------------------------------------------- 25

    1.7.5 The role of pro-inflammatory cytokines in β-cell apoptosis ---------------------------- 27 1.8 Apoptosis ----------------------------------------------------------------------------------------------- 30 1.9 Cell therapy -------------------------------------------------------------------------------------------- 33

    1.9.1 Stem cells ----------------------------------------------------------------------------------------- 34

    1.9.2 Mesenchymal stem cells (MSCs) ----------------------------------------------------------- 36

    1.9.2.1 Development and function of MSCs --------------------------------------------------- 37

    1.9.2.2 Clinical utility of MSCs -------------------------------------------------------------------- 38

    1.9.2.3 MSC and tissue repair -------------------------------------------------------------------- 39

    1.9.2.4 Immunomodulatory effect of MSC and diabetes------------------------------------ 40 1.10 Aims of this study ----------------------------------------------------------------------------------- 41 2.1 Materials ------------------------------------------------------------------------------------------------ 44 2.2 Methods------------------------------------------------------------------------------------------------- 50

    2.2.1 Cell Models --------------------------------------------------------------------------------------- 50

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