publication . Thesis

Hyaluronan and CD44 control of cell fate

Woods, Emma;
Open Access English
  • Country: United Kingdom
Fibrosis can be charactorised as abberent wound healing resulting from an increased presence of α-smooth muscle actin (αSMA)-rich, myofibroblasts and a continued influx of immune cell mediators. The pro-fibrotic and pro-inflammatory cytokines TGF-β1 and IL-1β, respectivley, have been implicated in fibrotic progression by activating hyaluronan (HA)/CD44-mediated pathways. CD44, the principal HA receptor, exists as multiple spliced variants which mediate multiple celluar functions through their association with HA. The aim of this Thesis was to investigate the expression and interactions of CD44 variants asociated with fibroblast activation induced by TGF-β1 or IL...
free text keywords: R1
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Kosaki, R. et al. 1999. Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity. Cancer Research 59(5), pp.

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