Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis

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Loveless, Samantha; Neal, James W.; Howell, Owain W.; Harding, Katharine; Sarkies, Patrick; Evans, Rhian; Bevan, Ryan J; Hakobyan, Svetlana; Harris, Claire; Robertson, Neil; Morgan, Bryan Paul;

BACKGROUND: The complement pathway has potential contributions to both white (WM) and grey matter (GM) pathology in Multiple Sclerosis (MS). A quantitative assessment of complement involvement is lacking. OBJECTIVE: Tissue MicroArray methodology was used in conjunction ... View more
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