publication . Thesis

Multifaceted aspects of MCR-mediated colistin resistance: Fitness, virulence, environmental reservoirs and genomic insights

Yang, Qiu;
Open Access English
  • Country: United Kingdom
Abstract
To date, eight different mcr-variants have been identified encoding phosphoethanolamine transferases contributing to phosphoethanolamine addition to lipid A and thereby conferring colistin resistance. This novel mechanism of plasmid-mediated colistin resistance provides an efficient way in distributing colistin resistance. This thesis aims to further our understanding of the multifaceted aspects of mcr-like genes using detailed molecular analysis including\ud whole-genome sequencing (WGS) for 17 mcr-positive Klebsiella pneumoniae (MCRPKP) and 219 mcr-positive Escherichia coli (MCRPEC) from Thailand and Vietnam.\ud Fitness is an important factor to predict the sp...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonists
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