Cathepsin S is the major activator of the psoriasis-associated pro-inflammatory cytokine IL-36γ

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Ainscough, JS; Macleod, T; McGonagle, D; Brakefield, R; Baron, JM; Alase, A; Wittmann, M; Stacey, MJ;
  • Publisher: National Academy of Sciences

The pro-inflammatory cytokine IL-36γ is highly expressed in epithelial cells and is a pivotal mediator of epithelial inflammation. In particular, IL-36γ is strongly associated with the inflammatory skin disease psoriasis. As with other IL-1 cytokines, IL-36γ is expresse... View more
  • References (16)
    16 references, page 1 of 2

    C. A. Dinarello, Immunological and inflammatory functions of the Interleukin-1 family.

    Annual Review of Immunology 27, 519-550 (2009).

    C. Gabay, C. Lamacchia, G. Palmer, IL-1 pathways in inflammation and human diseases.

    Nature Reviews Rheumatology 6, 232-241 (2010).

    A. H. Enk, V. L. Angeloni, M. C. Udey, S. I. Katz, An essential role for Langerhans cellderived IL-1-beta in the initiation of primary immune responses in the skin. Journal of Immunology 150, 3698-3704 (1993).

    M. Papini, P. L. Bruni, Cutaneous reactions to recombinant cytokine therapy. Journal of the American Academy of Dermatology 35, 1021-1021 (1996).

    a protein lacking A signal sequence. Embo Journal 9, 1503-1510 (1990).

    C. J. March et al., Cloning, sequence and expression of 2 distinct human interleukin-1 complementary DNAs. Nature 315, 641-647 (1985).

    N. A. Thornberry et al., A novel heterodimeric cysteine protease is required for interleukin-1- beta processing in monocytes. Nature 356, 768-774 (1992).

    Y. Ogura, F. S. Sutterwala, R. A. Flavell, The inflammasome: First line of the immune response to cell stress. Cell 126, 659-662 (2006).

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