Cathepsin S is the major activator of the psoriasis-associated pro-inflammatory cytokine IL-36γ

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Ainscough, JS; Macleod, T; McGonagle, D; Brakefield, R; Baron, JM; Alase, A; Wittmann, M; Stacey, MJ;
(2017)
  • Publisher: National Academy of Sciences

The pro-inflammatory cytokine IL-36γ is highly expressed in epithelial cells and is a pivotal mediator of epithelial inflammation. In particular, IL-36γ is strongly associated with the inflammatory skin disease psoriasis. As with other IL-1 cytokines, IL-36γ is expresse... View more
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