publication . Thesis

Development of nuclear magnetic resonance methods for determination of membrane protein structure

Patel, Dharmesh K.;
Open Access English
  • Country: United Kingdom
Membrane proteins represent over a third of all proteins encoded for by the human\ud genome and play a vital role in the functionality of the cell, by controlling a vast number of\ud cellular processes. With over half of pharmacological drugs targeting membrane proteins,\ud their importance is not to be under estimated. Yet the number of three-dimensional\ud membrane protein structures reported to date falls well short of that of their water soluble\ud counterparts. This discrepancy can directly be attributed to the difficulties involved in\ud studying membrane protein structure due to their hydrophobic nature, resulting in a\ud number of challenges in the produ...
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