publication . Article . Other literature type . 2017

Emerging therapeutic targets in cancer induced bone disease: A focus on the peripheral type 2 cannabinoid receptor

Marino, S.; Idris, A.;
Open Access English
  • Published: 01 May 2017
  • Publisher: Elsevier
  • Country: United Kingdom
Abstract
Skeletal complications are a common cause of morbidity in patients with primary bone cancer and bone metastases. The type 2 cannabinoid (Cnr2) receptor is implicated in cancer, bone metabolism and pain perception. Emerging data have uncovered the role of Cnr2 in the regulation of tumour–bone cell interactions and suggest that agents that target Cnr2 in the skeleton have potential efficacy in the reduction of skeletal complications associated with cancer. This review aims to provide an overview of findings relating to the role of Cnr2 receptor in the regulation of skeletal tumour growth, osteolysis and bone pain, and highlights the many unanswered questions and u...
Subjects
free text keywords: Pharmacology, Bone remodeling, Bone pain, medicine.symptom, medicine, Cannabinoid, medicine.medical_treatment, Biochemistry, Cancer, medicine.disease, Osteoporosis, Pathology, medicine.medical_specialty, Cannabinoid receptor, Bone disease, Osteolysis, Bioinformatics, business.industry, business
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