Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis

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Wickramasinghe, S.R.; Inglis, K.A.; Urch, J.E.; Müller, S.; van Aalten, D.M.; Fairlamb, A.H.;
  • Publisher: Portland Press Ltd.
  • Subject: QR180

Type II fatty acid biosynthesis represents an attractive target for the discovery of new antimalarial drugs. Previous studies have identified malarial ENR (enoyl acyl-carrier-protein reductase, or FabI) as the target for the antiseptic triclosan. In the present paper, w... View more
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