The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)

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Le Trionnaire, SV; Perry, A; Szczesny, B; Szabo, C; Winyard, PG; Whatmore, JL; Wood, ME; Whiteman, M;
  • Publisher: Royal Society of Chemistry
  • Subject:
    mesheuropmc: equipment and supplies

Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is perturbed in many disease states, including those involving mitochondrial dysfunction. There is intense interest in developing pharmacological agents to generate H2S. We have synthesi... View more
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