The Pro-Apoptotic JNK Scaffold POSH/SH3RF1 Mediates CHMP2BIntron5-Associated Toxicity in Animal Models Frontotemporal Dementia

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West, Ryan John Hatcher; Ugbode, Christopher; Gao, Fen-Biao; Sweeney, Sean;
  • Subject:
    mesheuropmc: mental disorders

Frontotemporal Dementia (FTD) is one of the most prevalent forms of early-onset dementia. However, the pathological mechanisms driving neuronal atrophy in FTD remain poorly understood. Here we identify a conserved role for the novel pro-apoptotic protein POSH/SH3RF1 in ... View more
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