publication . Thesis

Characterizing the roles of APC2 protein in ovarian homeostasis and tumourigenesis

Mohamed, Noha-Ehssan;
Open Access English
  • Country: United Kingdom
Abstract
Canonical WNT signalling plays a critical role in the regulation of ovarian development during embryogenesis; dysregulation of this pathway in adult ovary is associated with subfertility and tumourigenesis. The aim of the current study was to elucidate the previously unexplored roles of Adenomatous polyposis coli 2 (APC2), a WNT signalling pathway regulator, in the ovary using an Apc2 constitutive knockout mouse. For the first time, the current work demonstrated essential roles of APC2 in regulating ovarian WNT signalling and ovarian homeostasis. In early adulthood, APC2-deficiency resulted in WNT signalling activation and sub-fertility driven by intra-ovarian d...
Subjects
Medical Subject Headings: endocrine system
free text keywords: Q1, RB
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