A Mild Hydration of Nitriles Catalysed by Copper (ll) Acetate
- Publisher: Royal Society of Chemistry
A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.
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