Rational steering of insulin binding specificity by intra-chain chemical crosslinking

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Viková, Jitka; Collinsová, Michaela; Kletvíková, Emília; Budšínský, Miloš; Záková, Lenka; Veverka, Václav; Hexnerová, Rozálie; Aviñó, Roberto J Tarazona; Straková, Jana; Selicharová, Irena; Vank, Václav; Wright, Daniel W.; Watson, Christopher J.; Turkenburg, Johan P.; Brzozowski, Andrzej M.; Jiráek, Jí;
(2016)
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Insulin is a key hormone of human metabolism with major therapeutic importance for both types of diabetes. New insulin analogues with more physiological profiles and better glycemic control are needed, especially analogues that preferentially bind to the metabolic B-iso... View more
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