Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain

Article English OPEN
Hammond, Rachel; Vivancos, Valerie; Naeem, Arifa; Chilton, John; Mambetisaeva, Elvira; Andrews, William; Sundaresan, Vasi; Guthrie, Sarah;
  • Publisher: Company of Biologists
  • Identifiers: doi: 10.1242/dev.02038
  • Subject:
    mesheuropmc: nervous system | embryonic structures | animal structures

The floor plate is known to be a source of repellent signals for cranial motor axons, preventing them from crossing the midline of the hindbrain. However, it is unknown which molecules mediate this effect in vivo. We show that Slit and Robo proteins are candidate motor ... View more
  • References (56)
    56 references, page 1 of 6

    Anderson, C. N., Ohta, K., Quick, M. M., Fleming, A., Keynes, R. and Tannahill, D. (2003). Molecular analysis of axon repulsion by the notochord. Development 130, 1123-1133.

    Auclair, F., Valdes, N. and Marchand, R. (1996). Rhombomere-specific origin of branchial and visceral motoneurones of the facial nerve in the rat embryo. J. Comp. Neurol. 369, 451-461.

    Bagri, A., Marin, O., Plump, A. S., Mak, J., Pleasure, S. J., Rubenstein, J. L. and Tessier-Lavigne, M. (2002). Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron 33, 233-248.

    Bancroft, J. D. and Stevens, A. (1990). Theory and Practice of Histological Techniques. 3rd edn. London: Churchill Livingstone.

    Barrett, C. and Guthrie, S. (2001). Expression patterns of the netrin receptor UNC5H1 among developing motor neurons in the embryonic rat hindbrain. Mech. Dev. 106, 163-166.

    Brose, K., Bland, K. S., Wang, K. H., Arnott, D., Henzel, W., Goodman, C. S., Tessier-Lavigne, M. and Kidd, T. (1999). Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96, 795-806.

    Caton, A., Hacker, A., Naeem, A., Livet, J., Maina, F., Bladt, F., Klein, R., Birchmeier, C. and Guthrie, S. (2000). The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons. Development 127, 1751-1766.

    Chilton, J. and Guthrie, S. (2003). Cranial expression of class 3 secreted semaphorins. Dev. Dyn. 228, 726-733.

    Colamarino, S. and Tessier-Lavigne, M. (1995). The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621- 629.

    Cowan, C. A., Yokoyama, M., Bianchi, L. M., Henkemeyer, M. and Frizsch, B. (2000). EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron 26, 417-430.

  • Metrics
Share - Bookmark