Stability enhancing N-Terminal PEGylation of oxytocin exploiting different polymer architectures and conjugation approaches

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Collins, Jennifer; Kempe, Kristian; Wilson, Paul; Blindauer, Claudia A.; McIntosh, Michelle P.; Davis, Thomas P.; Whittaker, Michael R.; Haddleton, David M.;
(2016)

Oxytocin, a cyclic nine amino acid neurohypophyseal hormone therapeutic, is effectively used in the control of postpartum hemorrhaging (PPH) and is on the WHO List of Essential Medicines. However, oxytocin has limited shelf life stability in aqueous solutions, particula... View more
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