publication . Article . 2015

effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes

Cheng, Z R; Abayasekara, D R E; Elmes, M; Kirkup, S E; Wathes, D C;
Open Access
  • Published: 23 Jul 2015 Journal: Placenta, volume 36, pages 1,011-1,017 (issn: 0143-4004, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract Introduction Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition. We investigated the effect of OA supplementation on PG production using an in vitro model of ovine placenta. Methods Maternal endometrium (ME) and fetal allantochorion (FC) were collected in late pregnancy (day 135). Confluent cells were cultured in serum-free medium supplemented with 0, 20 or 100 μM OA and challenged with control medium, oxytocin (OT, 250 nM), lipopolysaccharide (LPS, 0.1 μg/ml) or dexamethasone (DEX, 5 μM). Spent medium was harvested...
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Obstetrics and Gynaecology, Developmental Biology, Reproductive Medicine, Endocrinology, medicine.medical_specialty, medicine, Endometrium, medicine.anatomical_structure, Oxytocin, medicine.drug, Prostaglandin, chemistry.chemical_compound, chemistry, Placenta, Lipopolysaccharide, Dexamethasone, Internal medicine, Biology, Fetus, Gestation
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