publication . Article . 2015

effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes

Cheng, Z R; Abayasekara, D R E; Elmes, M; Kirkup, S E; Wathes, D C;
Open Access
  • Published: 23 Jul 2015 Journal: Placenta, volume 36, pages 1,011-1,017 (issn: 0143-4004, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Abstract Introduction Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition. We investigated the effect of OA supplementation on PG production using an in vitro model of ovine placenta. Methods Maternal endometrium (ME) and fetal allantochorion (FC) were collected in late pregnancy (day 135). Confluent cells were cultured in serum-free medium supplemented with 0, 20 or 100 μM OA and challenged with control medium, oxytocin (OT, 250 nM), lipopolysaccharide (LPS, 0.1 μg/ml) or dexamethasone (DEX, 5 μM). Spent medium was harvested...
Subjects
Medical Subject Headings: lipids (amino acids, peptides, and proteins)
free text keywords: Obstetrics and Gynaecology, Developmental Biology, Reproductive Medicine, Endocrinology, medicine.medical_specialty, medicine, Endometrium, medicine.anatomical_structure, Oxytocin, medicine.drug, Prostaglandin, chemistry.chemical_compound, chemistry, Placenta, Lipopolysaccharide, Dexamethasone, Internal medicine, Biology, Fetus, Gestation
17 references, page 1 of 2

[1] Chu SY, Kim SY and Bish CL. Prepregnancy obesity prevalence in the United States, 2004-2005. Matern Child Health J 2009; 13(5):614-20.

[2] Robinson NJ, Minchell LJ, Myers JE, Hubel CA and Crocker IP. A potential role for free fatty acids in the pathogenesis of preeclampsia. J Hypertens 2009; 27(6):1293-302.

[3] Catov JM, Bertolet M, Chen YF, Evans RW and Hubel CA. Nonesterified fatty acids and spontaneous preterm birth: a factor analysis for identification of risk patterns. Am J Epidemiol 2014; 179(10):1208-15.

[4] Zhang J, Bricker L, Wray S and Quenby S. Poor uterine contractility in obese women. BJOG 2007; 114(3):343-8.

[5] Crane SS, Wojtowycz MA, Dye TD, Aubry RH and Artal R. Association between prepregnancy obesity and the risk of cesarean delivery. Obstet Gynecol 1997; 89(2):213-6.

[6] Villa PM, Laivuori H, Kajantie E and Kaaja R. Free fatty acid profiles in preeclampsia. Prostaglandins Leukot Essent Fatty Acids 2009; 81(1):17-21.

[7] Nielsen TS, Jessen N, Jorgensen JO, Moller N and Lund S. Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease. J Mol Endocrinol 2014; 52(3):R199-222.

[8] Noble RC, Steele W and Moore JH. The plasma lipids of the ewe during pregnancy and lactation. Res Vet Sci 1971; 12(1):47-53.

[9] Chen X, Scholl TO, Leskiw M, Savaille J and Stein TP. Differences in maternal circulating fatty acid composition and dietary fat intake in women with gestational diabetes mellitus or mild gestational hyperglycemia. Diabetes Care 2010; 33(9):2049-54.

[10] Witkin SS, Skupski D, Herway C, Rudge MV, Saito F and Harris M. Fatty acid composition of mid-trimester amniotic fluid in women of different ethnicities. J Matern Fetal Neonatal Med 2012; 25(6):818-21. [OpenAIRE]

[11] Kim PY, Zhong M, Kim YS, Sanborn BM and Allen KG. Long chain polyunsaturated fatty acids alter oxytocin signaling and receptor density in cultured pregnant human myometrial smooth muscle cells. PLoS One 2012; 7(7):e41708.

[12] Carluccio MA, Massaro M, Bonfrate C, Siculella L, Maffia M, Nicolardi G, Distante A, Storelli C and De Caterina R. Oleic acid inhibits endothelial activation : A direct vascular antiatherogenic mechanism of a nutritional component in the mediterranean diet. Arterioscler Thromb Vasc Biol 1999; 19(2):220-8. [OpenAIRE]

[13] Lunn J and Theobald HE. The health effects of dietary unsaturated fatty acids. Nutrition Bulletin 2006; 31(3):178-224.

[14] Alves RD, Moreira AP, Macedo VS, de Cassia Goncalves Alfenas R, Bressan J, Mattes R and Costa NM. Regular intake of high-oleic peanuts improves fat oxidation and body composition in overweight/obese men pursuing a energy-restricted diet. Obesity (Silver Spring) 2014; 22(6):1422-9.

[15] Guillou H, D'Andrea S, Rioux V, Jan S and Legrand P. The surprising diversity of Delta6-desaturase substrates. Biochem Soc Trans 2004; 32(Pt 1):86-7.

17 references, page 1 of 2
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue