Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis

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Zhang, Min; Wang, Chengqi; Otto, Thomas D.; Oberstaller, Jenna; Liao, Xiangyun; Adapa, Swamy R.; Udenze, Kenneth; Bronner, Iraad F.; Casandra, Deborah; Mayho, Matthew; Brown, Jacqueline; Li, Suzanne; Swanson, Justin; Rayner, Julian C.; Jiang, Rays H. Y.; Adams, John H.;
  • Publisher: American Association for the Advancement of Science

Malaria is caused by eukaryotic Plasmodium spp. parasites that classically infect red blood cells. These are difficult organisms to investigate genetically because of their AT-rich genomes. Zhang et al. have exploited this peculiarity by using piggyBac transposon insert... View more
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