Over 200 000 adults a year sustain a cardiac arrest while in hospital in the United States.1 Most trials have taken place outside hospital,2 yet the aetiology, patient characteristics, time to treatment, and outcomes are quite different to cardiac arrests occurring in i... View more
2 Whitehead L, Perkins GD, Clarey A, Haywood KL. A systematic review of the outcomes reported in cardiac arrest clinical trials: the need for a core outcome set. Resuscitation 2015;88:150- 7. PubMed 3 Nolan JP, Hazinski MF, Aickin R, et al. Part 1: Executive summary: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Resuscitation 2015;95:e1-31. PubMed doi:10.1016/j.resuscitation.2015.07.039 4 Kitsios GD, Dahabreh IJ, Callahan S, Paulus JK, Campagna AC, Dargin JM. Can We Trust Observational Studies Using Propensity Scores in the Critical Care Literature? A Systematic Comparison With Randomized Clinical Trials. Crit Care Med 2015;43:1870-9. PubMed doi:10.1097/CCM.0000000000001135 5 Olasveengen TM. Adrenaline for out of hospital cardiac arrest? BMJ 2013;347:f7268.
PubMed doi:10.1136/bmj.f7268 6 Bradley SM, Liu W, Chan PS, et al. Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry. BMJ 2016;353:i1653.
7 Andersen LW, Kurth T, Chase M, et al. Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. BMJ 2016;353:i1577.
8 Hazinski MF, Nadkarni VM, Hickey RW, O'Connor R, Becker LB, Zaritsky A. Major changes in the 2005 AHA Guidelines for CPR and ECC: reaching the tipping point for change. Circulation 2005;112(Suppl):IV206-11. PubMed doi:10.1161/CIRCULATIONAHA.105.170809 9 Donnino MW, Salciccioli JD, Howell MD, et al; American Heart Association's Get With The Guidelines-Resuscitation Investigators. Time to administration of epinephrine and outcome after inhospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry. BMJ 2014;348:g3028. PubMed doi:10.1136/bmj.g3028