Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

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Monteiro, DCF ; Phillips, Roger ; Crossley, BD ; Fielden, J ; Willans, CE (2012)
  • Publisher: Royal Society of Chemistry
  • Subject: RM

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.
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