ADP binding induces an asymmetry between the heads of unphosphorylated myosin.

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Berger, C.E.M.; Fagnant, P.M.; Heizmann, S.; Trybus, K.M.; Geeves, Michael A.;

Light chain phosphorylation is the key event that regulates smooth and non-muscle myosin II ATPase activity. Here we show that both heads of smooth muscle heavy meromyosin (HMM) bind tightly to actin in the absence of nucleotide, irrespective of the state of light chain... View more
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