Input estimation in nonlinear dynamical systems for drug-discovery applications.

0044 English OPEN
Trägårdh, Magnus;
  • Subject: RM

In mathematical modelling for drug discovery, nonparametric methods are an alternative to the more commonly used parametric methods, and have the advantage of requiring fewer modelling assumptions. This thesis considers nonparametric methods for performing input estimat... View more
  • References (65)
    65 references, page 1 of 7

    1. Magnus Tra¨g˚ardh, Michael J Chappell, Andrea Ahnmark, Daniel Lind´en, Neil D Evans and Peter Gennemark. 'Input estimation for drug discovery using optimal control and Markov chain Monte Carlo approaches'. In: Journal of Pharmacokinetics and Pharmacodynamics 43.2 (2016), pp. 207-221, doi: 10.1007/s10928-016-9467-z

    2. Magnus Tr¨ag˚ardh, Michael J Chappell, Johan E Palm, Neil D Evans, David LI Janz´en and Peter Gennemark. 'Input Estimation for Extended-Release Formulations Exemplified with Exenatide'. In: Frontiers in Bioengineering and Biotechnology 5 (2017), p. 24, doi: 10.3389/fbioe.2017.00024

    3. Peter Gennemark, Magnus Tr¨ag˚ardh, Daniel Lind´en, Karolina Ploj, Anders Johansson, Andrew Turnbull, Bjo¨rn Carlsson and Madeleine Antonsson. 'Translational Modeling to Guide Study Design and Dose Choice in Obesity Exemplified by AZD1979, a Melanin-concentrating Hormone Receptor 1 Antagonist'. In: CPT: Pharmacometrics & Systems Pharmacology 6.7 (2017), pp. 458-468, doi: 10.1002/psp4.12199

    1. Poster: Magnus Tra¨g˚ardh, Michael J Chappell, Neil D Evans, Mats Jirstrand, Johan Gabrielsson, Peter Gennemark. 'Input Estimation in Nonlinear Ordinary Differential Equations for Quantitative and Systems Pharmacology'. Presented at PKUK, Harrogate, UK, 1-2 November 2013 and at the AstraZeneca Modelling & Simulation Symposium, Alderley Park, UK, 3-4 December 2013.

    2. Poster: Robert Andersson, David LI Janz´en, Magnus Tr¨ag˚ardh, Michael J Chappell, Neil D Evans, Johan Gabrielsson, Peter Gennemark, Mats Jirstrand, Lambertus Peletier, James Yates. 'Dose-Response-Time Modelling, Input Estimation and Structural Identifiability as tools for Systems Pharmacology'. Presented at the Noordwijkerhout Symposium on Pharmacokinetics, Pharmacodynamics and Systems Pharmacology, Noordwijkerhout, the Netherlands, 23-25 April 2014 and at the Chalmers Life Science Area of Advance Meeting, Gothenburg, Sweden, 5 May 2014.

    3. Poster: Magnus Tra¨g˚ardh, Michael J Chappell, Neil D Evans, Mats Jirstrand, Johan Gabrielsson, Peter Gennemark. 'Input estimation in nonlinear dynamical systems for model-based drug discovery using optimal control techniques'. Presented at PKUK, Bath, UK, 4-6 November 2014 and at the AstraZeneca Modelling & Simulation Symposium, Mo¨lndal, Sweden, 17-19 December 2014.

    4. Poster: Magnus Tra¨g˚ardh, Michael J Chappell, Neil D Evans, Johan Gabrielsson, Peter Gennemark. 'Input estimation for systems pharmacology'. Presented at the Third School of Engineering Annual Postgraduate Symposium, University of Warwick, UK, 9 March 2015.

    5. Oral presentation: 'Input estimation in nonlinear dynamical systems for Quantitative and Systems Pharmacology'. Presented at the Population Pharmacokinetics, Parameter Estimation and Model Validation Vacation School, University of Warwick, UK, 21-25 September 2015.

    6. Poster: Magnus Tra¨g˚ardh, Michael J Chappell, Neil D Evans, Peter Gennemark.

    7. Oral presentation: 'Input estimation in nonlinear dynamical systems for Quantitative and Systems Pharmacology'. Presented at the Fourth School of Engineering Postgraduate Symposium, University of Warwick, UK, 22 April 2016.

  • Related Research Results (1)
  • Metrics
Share - Bookmark