Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients

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Powell, Jason; Garnett, James; Mather, Michael W.; Cooles, Faye A. H.; Nelson, Andrew; Verdon, Bernard; Scott, Jon; Jiwa, Kasim; Ruchaud-Sparagano, Marie-Hélène; Cummings, Stephen; Perry, John; Wright, Stephen; Wilson, Janet; Pearson, Jeffrey; Ward, Chris; Simpson, A. John;

Rationale:\ud Aspiration of infective subglottic secretions causes ventilator-associated pneumonia (VAP) in mechanically ventilated patients. Mechanisms underlying subglottic colonization in critical illness have not been defined, limiting strategies for targeted preven... View more
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