publication . Article . 2016

Repurposing drugs for treatment of tuberculosis (TB): a role for non-steroidal anti-inflammatory drugs.

Maitra, Arundhati; Bhakta, Sanjib; Evangelopoulos, Dimitrios;
Open Access English
  • Published: 10 Jun 2016
  • Publisher: Oxford Journals
  • Country: United Kingdom
Abstract
Introduction \ud The number of cases of drug-resistant Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has risen rapidly in recent years. This has led to the resurgence in repurposing existing drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), for anti-TB treatment. \ud Sources of data\ud Evidence from novel drug screening in vitro, in vivo, pharmacokinetic/pharmacodynamics analyses and clinical trials has been used for the preparation of this systematic review of the potential of NSAIDs for use as an adjunct in new TB chemotherapies. \ud Areas of agreement\ud Certain NSAIDs have demonstrated inhibitory properties towards active...
Subjects
free text keywords: bcs
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
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