Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors

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Carrington, Louise Mary; Albon, Julie; Anderson, Ian; Kamma-Lorger, Christina S.; Boulton, Michael Edwin;

PURPOSE: Inhibition of TGF-beta reduces myofibroblast differentiation and fibrosis in the cornea. Determining the actions of distinct TGF-beta isoforms and their inhibitors during early corneal wound healing is an essential step in guiding therapeutic intervention. METH... View more
  • References (41)
    41 references, page 1 of 5

    1. O'Kane S, Ferguson M. Transforming growth factor betas and wound healing. Int J Biochem Cell Biol. 1997;29:63-78.

    2. Møller-Pedersen T, Cavanagh H, Petroll W, Jester J. Neutralising antibody to TGF-beta modulates stromal fibrosis but not regression of photoablative effect following PRK. Curr Eye Res. 1998;17: 736 -747.

    3. Jester JV, BarryLane PA, Petroll WM, Olsen DR, Cavanagh HD. Inhibition of corneal fibrosis by topical application of blocking antibodies to TGF(beta) in the rabbit. Cornea. 1997;16:177-187.

    4. Nishida K, Kinoshita S, Yokoi N, et al. Immunohistochemical localization of transforming growth factor-beta-1, factor-beta-2, and factor-beta-3 latency-associated peptide in human cornea. Invest Ophthalmol Vis Sci. 1994;35:3289 -3294.

    5. Nishida K, Sotozono C, Adachi W, Yamamoto S, Yokoi N, Kinoshita S. Transforming growth factor 1, - 2 and - 3 mRNA expression in human cornea. Curr Eye Res. 1995;14:235-241.

    6. Pasquale LR, Dorman-Pease ME, Lutty GA, et al. Immunolocalization of Tgf-beta-1, Tgf-beta-2, and Tgf-beta-3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci. 1993;34:23- 30.

    7. Abrahamian A, Xi MS, Donnelly JJ, Rockey JH. Effect of interferongamma on the expression of transforming growth-factor-beta by human corneal fibroblasts: role in corneal immunoseclusion J Interferon Cytokine Res. 1995;15:323-330.

    8. Chen KH, Harris DL, Joyce NC. TGF-beta 2 in aqueous humor suppresses S-phase entry in cultured corneal endothelial cells. Invest Ophthalmol Vis Sci. 1999;40:2513-2519.

    9. Gupta A, Monroy D, Ji Z, Yoshino K, Huang A, Pflugfelder S. Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res. 1996;15:605- 614.

    10. Chen C, Michelini-Norris B, Stevens S, et al. Measurement of mRNAs for TGF beta and extracellular matrix proteins in corneas of rats after PRK. Invest Ophthalmol Vis Sci. 2000;41:4108 - 4116.

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