publication . Article . 2018

Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats

Geddes, R F; Jepson, R E; Forcada, Y; Elliott, J; Syme, H M;
Open Access English
  • Published: 21 Feb 2018
  • Country: United Kingdom
Abstract
Feline chronic kidney disease (CKD) is associated with high variability in severity of CKD-mineral and bone disorder (CKD-MBD). The calcium sensing receptor (CaSR) regulates circulating parathyroid hormone (PTH) and calcium concentrations. Single nucleotide polymorphisms (SNPs) in the CaSR are associated with severity of secondary renal hyperparathyroidism and total calcium concentrations in human patients receiving haemodialysis. The objective of this study was to explore associations between polymorphisms in the feline CaSR (fCaSR) and biochemical changes observed in CKD-MBD.\ud \ud Client owned cats (≥ 9 years) were retrospectively included. SNP discovery was...
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