The role of setting for ketamine abuse: clinical and preclinical evidence

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De Luca, Maria Teresa ; Meringolo, Maria ; Spagnolo, Primavera Alessandra ; Badiani, Aldo (2012)

Drug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug. This is particularly evident in the case of 'club drugs', such as ketamine. Although the number of ketamine abusers is relatively small in the general population, it is quite substantial in some settings. In particular, ketamine abuse is almost exclusively limited to clubs and large music parties, which suggests a major role of context in modulating the reward effects of this drug. This review focuses on recent preclinical and clinical findings, including previously unpublished data, that provide evidence that, even under controlled conditions, ketamine reward is a function of the setting of drug taking.
  • References (94)
    94 references, page 1 of 10

    Adler, C.M., Malhotra, A.K., Elman, I., Goldberg, T., Egan, M., Pickar, D., and Breier, A. (1999). Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia. Am. J. Psychiatry 156, 1646-1649.

    Anis, N.A., Berry, S.C., Burton, N.R., and Lodge, D. (1983). The dissociative anesthetics ketamine and phencyclidine, selectively reduce excitation of central mammalian neurons by N-methyl-aspartate. Br. J. Pharmacol. 79, 565-575.

    Aro, S. (1981). Stress, morbidity, and health-related behaviour. A five-year follow-up study among metal industry employees. Scand. J. Soc. Med. Suppl. 25, 1-130.

    Aroni, F., Iacovidou, N., Dontas, I., Pourzitaki, C., and Xanthos, T. (2009). Pharmacological aspects and potential new clinical applications of ketamine: reevaluation of an old drug. J. Clin. Pharmacol. 49, 957-964.

    Badiani, A., Belin, D., Epstein, D., Calu, D., and Shaham, Y. (2011). Opiate versus psychostimulant addiction: the differences do matter. Nature Rev. Neurosci. 12, 685-700.

    Baumgartner, E. (2007). Ketamin als Partydroge. Zum Risiko konsum bedingter sozial pathologischer Veranderungen und spezifischer Konfliktmuster sowie deren Relevanz fur sekundar praventive Einrichtungen (Verein: Wiener).

    Bergman, S.A. (1999). Ketamine: Review of its pharmacology and its use in pediatric anesthesia. Anesth. Prog. 46, 10-20.

    Bevan, R.K., Rose, M.A., and Duggan, K.A. (1997). Evidence for direct interaction of ketamine with alpha 1- and beta 2-adrenoceptors. Clin. Exp. Pharmacol. Physiol. 24, 923-926.

    Bowdle, T.A., Radant, A.D., Cowley, D.S., Kharasch, E.D., Strassman, R.J., and Roy-Byrne, P.P. (1998). Psychedelic effects of ketamine in healthy volunteers. Anesthesiology 88, 82-88.

    Brady, K.T., Dansky, B.S., Back, S.E., Foa, E.B., and Carroll, K.M. (2001). Exposure therapy in the treatment of PTSD among cocaine-dependent individuals: Preliminary findings. J. Subst. Abuse Treat. 21, 47-54.

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