Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial.

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Paton, NI; Kityo, C; Thompson, J; Nankya, I; Bagenda, L; Hoppe, A; Hakim, J; Kambugu, A; van Oosterhout, JJ; Kiconco, M; Bertagnolio, S; Easterbrook, PJ; Mugyenyi, P; Walker, AS; Europe Africa Research Network for Evaluation of Second-line The; COLLABORATORS; Agweng, E; Awio, P; Bakeinyaga, G; Isabirye, C; Kabuga, U; Kasuswa, S; Katuramu, M; Kityo, C; Kiweewa, F; Kyomugisha, H; Lutalo, E; Mugyenyi, P; Mulima, D; Musana, H; ... view all 293 authors
  • Publisher: Elsevier
  • Subject:
    mesheuropmc: immune system diseases | virus diseases

Cross-resistance after first-line antiretroviral therapy (ART) failure is expected to impair activity of nucleoside reverse-transcriptase inhibitors (NRTIs) in second-line therapy for patients with HIV, but evidence for the effect of cross-resistance on virological outc... View more
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