publication . Article . 2012

Diallyl Disulfide-Induced Apoptosis in a Breast-Cancer Cell Line (MCF-7) May Be Caused by Inhibition of Histone Deacetylation

Mohammed Omar Altonsy;
Open Access
  • Published: 19 Nov 2012 Journal: Nutrition and Cancer, volume 64, pages 1,251-1,260 (issn: 0163-5581, eissn: 1532-7914, Copyright policy)
  • Publisher: Informa UK Limited
  • Country: United Kingdom
Abstract
The health benefits of garlic have been proven by epidemiological and experimental studies. Diallyl disulphide (DADS), the major organosulfur compound found in garlic oil, is known to lower the incidence of breast cancer both in vitro and in vivo. The studies reported here demonstrate that DADS induces apoptosis in the MCF-7 breast-cancer cell line through interfering with cell-cycle growth phases in a way that increases the sub-G0 population and substantially halts DNA synthesis. DADS also induces phosphatidylserine (PS) translocation from the inner to the outer leaflet of the plasma membrane and activates caspase-3. Further studies revealed that DADS modulates...
Subjects
free text keywords: Nutrition and Dietetics, Medicine (miscellaneous), Cancer Research, Oncology, Biochemistry, Phosphatidylserine, chemistry.chemical_compound, chemistry, Population, education.field_of_study, education, Cancer cell, MCF-7, Diallyl disulfide, Apoptosis, Acetylation, Biology, Cancer, medicine.disease, medicine
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